論文 of web




Kozako T, Sato K, Uchida Y, Kato N, Aikawa A, Ogata K, Kamimura H, Uemura H, Yoshimitsu M, Ishitsuka K, Higaki Y, Tanaka H, Honda SI, Soeda S.
The small molecule STF-62247 induces apoptotic and autophagic cell death in leukemic cells
Oncotarget 9 27645-27655, 2018

Kozako T, Soeda S, Yoshimitsu M, Arima N, Kuroki A, Hirata S, Tanaka H, Imakyure O, Tone N, Honda S, Soeda S
Angiotensin II type 1 receptor blocker telmisartan induces apoptosis and autophagy in adult T-cell leukemia cells
FEBS openbio 6 442–460, 2016

Takemoto S, Kozako T, Pornkuna R.
Shedding by ADAM10 and ADAM17 is associated with progression of adult T-cell leukemia/lymphoma
Integrative Cancer Science and Therapeutics 2 79-81, 2015

Uchiyama H, Hiromura M, Shiratani T, Kuroki H, Honda S, Kosako K, Soeda S, Inoue K, Toda A.
Effect of adenosine system in the action of oseltamivir on behavior in mice.
Neurosci Lett. 599 7-11, 2015

Masamoto I, Yoshimitsu M, Kuroki A, Horai S, Ezinne CC, Kozako T, Hachiman M, Kamada Y, Baba M, Arima N.
Clinical significance of CD70 expression on T cells in human T-lymphotropic virus type-1 carriers and adult T cell leukemia/lymphoma patients
Leuk Lymphoma. 25 1-7 2015

Kozako T, Suzuki T, Yoshimitsu M, Uchida Y, Kuroki A, Aikawa A, Honda SI, Arima N, Soeda S.
Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells
Sci Rep. 5 11345 2015

Kurokawa, J., Sasano, T., Kodama, M., Li, M., Ebana, Y., Harada, N., Honda, S., Nakaya, H., Furukawa, T
Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters
J Toxicol Sci 40 339-348 2015

Akimoto M, Yunoue S, Otsubo H, Yoshitama T, Kodama K, Matsushita K, Suruga Y, Kozako T, Toji S, Hashimoto S, Uozumi K, Matsuda T, Arima N.
Assessment of peripheral blood CD4+ adenosine triphosphate activity in patients with rheumatoid arthritis.
Mod Rheumatol. 23 19-27, 2013.

White Y, Yoshimitsu M, Kozako T, Matsushita K, Koriyama C, Uozumi K, Suzuki S, Kofune H, Arima N.
Effects of exogenous interleukin-7 on CD8(+) T-cell survival and function in human T-cell lymphotropic virus type 1 (HTLV-1) infection.
Leuk Lymphoma 54 2243-50, 2013.

Kozako T, Aikawa A, Shoji T, Fujimoto T, Yoshimitsu M, Shirasawa S, Tanaka H, Honda SI, Shimeno H, Arima N, Soeda S.
High expression of the longevity gene product SIRT1, and apoptosis induction by sirtinol in adult T-cell leukemia cells.
Int J Cancer, 131: 2044-2055,2012.

Honda SI, Kozako T, Shimeno H, Soeda S, Harada N.
LIM-homeodomain transcription factor, Lhx2, is involved in transcriptional control of brain-specific promoter/exon 1f of the mouse aromatase gene
J Neuroendocrinol., 34:1367-1374,2012

Kozako T, Matsumoto N, Kuramoto Y, Sakata A, Motonagare R, Aikawa A, Imoto M, Toda A, Honda S, Shimeno H, Soeda S.
Vasohibin induces prolyl hydroxylase-mediated degradation of hypoxia-inducible factor-1α in human umbilical vein endothelial cells
FEBS Lett., 586:1067-1072,2012.

Honda S., Wakatsuki T., Harada N.
Behavioral analysis of genetically modified mice indicates essential roles of neurosteroidal estrogen.
Front. Endocrinol. 2011.

Kozako T, Yoshimitsu M, Akimoto M, White Y, Matushita K, Soeda S, Shimeno H, Kubota R, Izumo S, Arima N.
PD-1/PD-L1 Pathway-Mediated Immune Responses Against Human T-Lymphotropic Virus Type I in HAM/TSP and Carriers with Collagen Diseases.
Human Immunology 72 1001-1006, 2011.

Kozako T.
New Strategy of Adult T-cell Leukemia Treatment Targeted for Anti-tumor Immunity and a Longevity Gene-encoded Protein.
Yakugaku Zasshi. 1311061-72, 2011

Kozako T, Akimoto M, Toji S, White Y, Suzuki S, Arima T, Suruga Y, Matsushita K, Shimeno H, Soeda S, Kubota R, Izumo S, Uozumi K, Arima N.
Target epitopes of HTLV-1 recognized by class I MHC-restricted cytotoxic T lymphocytes in patients with myelopathy and spastic paraparesis and infected patients with autoimmune disorders.
J Med Virol. 83 501-509, 2011

Kozako T, Hirata S, Shimizu Y, Satoh Y, Yoshimitsu M, White Y, Lemonnier F, Shimeno H, Soeda S, Arima N.
Oligomannose-coated liposomes efficiently induce human T-cell leukemia virus-1-specific cytotoxic T lymphocytes without adjuvant.
FEBS J. 278 1358-66, 2011

White Y, Hamada T, Yoshimitsu M, Nakashima M, Hachiman M, Kozako T, Matsushita K, Uozumi K, Suzuki S, Kofune H, Furukawa T, Arima N.
Novel Cytotoxic Isolated from Jamaican Hyptis verticillata jacq Induces Apoptosis and Overcomes Multidrug Resistance.
Anticancer Res. 31 4251-4257, 2011

Hayashida S, Kuramoto Y, Koyanagi S, Oishi K, Fujiki J, Matsunaga N, Ikeda E, Ohdo S, Shimeno H, Soeda S. Proxisome proliferator-activated receptor-α mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice. Chronobiol Int. 27 1735-53, 2010

McAllister C., Long J., Bowers A., Walker A., Cao P., Honda S., Harada N., Staufenbiel M., Shen Y. and Li R. Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. J. Neuroscience 30 7326-7334, 2010

Juntti S. A., Tollkuhn J., Wu M. V., Fraser E. J., Soderborg T.,Tan S., Honda S., Harada N. and Shah N. M. The androgen receptor governs the execution, but not programming, of male sexual and territorial behaviors. Neuron 66 260-272, 2010

Hayashida, S., Arimoto, A., Kuramoto, Y, Kozako, T., Honda, S., Shimeno, H., Soeda, S. Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice. Mol Cell Biochem. 339:285-92, 2010

Uchiyama H, Toda A, Imoto M, Nishimura S, Kuroki H, Soeda S, Shimeno H, Watanabe S, Eyanagi R.
The stimulatory effects of caffeine with oseltamivir (Tamiflu) on light-dark behavior and open-field behavior in mice.
Neurosci Lett. 469(2):184-8, 2010

Oishi K, Koyanagi S, Matsunaga N, Kadota K, Ikeda E, Hayashida S, Kuramoto Y, Shimeno H, Soeda S, Ohdo S. 
Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner. Mol Pharmacol. [Epub ahead of print], 2010

Kozako T, Fukada K, Hirata S, White Y, Harao M, Nishimura Y, Kino Y, Soeda S, Shimeno H, Lemonnier F, Sonoda S, Arima N. Efficient induction of human T-cell leukemia virus-1-specific CTL by chimeric particle without adjuvant as a prophylactic for adult T-cell leukemia. Mol Immunol., 47:606-613, 2009.

Kozako, T., Yoshimitsu, M., Fujiwara, H., Masamoto I., Horai S., White Y., Akimoto M., Suzuki S., Uozumi K., Tei C., Arima N. PD-1/PD-L1 expression in HTLV-1 carriers and adult T-cell leukemia/lymphoma patients. Leukemia, 23:375-382, 2009.

Wu, M. V., Manoli, D. S., Fraser, E. J., Coats, J. K., Tollkuhn, J., Honda, S., Harada, N., Shah, N. M. Estrogen masculinizes neural pathways and sex-specific behaviors. Cell, 139:61-72, 2009.

Harada N., Wakatsuki T., Aste N., Yoshimura N., Honda S. Functional analysis of neurosteroidal oestrogen using gene-disrupted and transgenic mice. J. Neuroendocrinol, 21:365-369, 2009.

Kudawa A.E., Harada N., Honda S-I., Rissman E.F. Regulation of progestin receptors in medial amygdala: estradiol, phytoestrogens and sex. Physiol. Behav., 97:146-150, 2009.

Yamagishi T, Muronoi S, Hikishima S, Shimeno H, Soeda S, Yokomatsu T. Diastereoselective Synthesis of gamma-Amino-delta-hydroxy-alpha,alpha-difluorophosphonates: A Vehicle for Structure-activity Relationship Studies on SMA-7, a Potent Sphingomyelinase Inhibitor. J Org Chem., 74:6350-6353, 2009.

Ochiai T, Takenaka Y, Kuramoto Y, Kasuya M, Fukuda K, Kimura M, Shimeno H, Misasi R, Hiraiwa M, Soeda S.: Molecular mechanism for neuro-protective effect of prosaposin against oxidative stress: its regulation of dimeric transcription factor formation. Biochim. Biophys. Acta, 1780: 1441-1447, 2008.

Nakagawa H, Koyanagi S, Kuramoto Y, Yoshizumi A, Matsunaga N, Shimeno H, Soeda S, Ohdo S.: Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling. J. Pharmacol. Sci., 107: 401-407, 2008.

Ochiai T, Fukuda K, Kasuya M, Sakata A, Shimeno H, Toda A, Eyanagi R, Soeda S.: Cholesterol-independent, MAPK/ERK signal-mediated simvastatin potentiation of nerve growth factor-induced neurite outrowth in PC12 cells. Pharmaceut. Bull. Fukuoka Univ., 8: 146-159, 2008.

Sakata A, Ochiai T, Shimeno H, Hikishima S, Yokomatsu T, Shibuya S, Toda A, Eyanagi R, Soeda S.: Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis in mice. Immunology, 122: 54-64, 2007.

Sakata A, Yasuda K, Ochiai T, Shimeno H, Hikishima S, Yokomatsu T, Shibuya S, Soeda S.: Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a nobel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice. Cell. Immunol., 245: 24-31, 2007.

Ochiai T, Shimeno H, Mishima K, Iwasaki K, Fujiwara M, Tanaka H, Shoyama Y, Toda A, Eyanagi R, Soeda S.: Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim. Biophys. Acta, 1770: 578-584, 2007.

Koyanai S, Suyama H, Kuramoto Y, Matsunaga N, Takane H, Soeda S, Shimeno H, Higuchi S, Ohdo S. : Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver. Endocrinology, 147:5034-5040, 2006.

Soeda S, Shinomiya K, Ochiai T, Koyanagi S, Toda A, Eyanagi R, Shimeno H. Plasminogen activator inhibitor-1 aids nerve growth factor-induced differentiation and survival of pheochromocytoma cells by activating both the extracellular signal-regulated kinase and c-Jun pathways. Neuroscience, 141: 101108, 2006.

Koyanagi S, Okazawa S, Kuramoto Y, Ushijima K, Shimeno H, Soeda S, Okamura H, Ohdo S. : Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues. Mol. Endocrinol., 20: 573583, 2006.

Kuramoto Y, Hata K, Koyanagi S, Ohdo S, Shimeno H, Soeda S. : Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones. Biochem. Pharmacol., 71: 11551161, 2006.

Hikishima S, Isobe M, Koyanagi S, Soeda S, Shimeno H, Shibuya S, Yokomatsu T. : Synthesis and biological evaluation of 9-(5’,5’-difluoro-5’-phosphonopentyl)guanine derivatives for PNP-inhibitors. Bioorg. Med. Chem, 14: 16601670, 2006.

Eyanagi R, Toda A, Ishii Y, Saito H, Soeda S, Shimeno H, Shigematsu H. : Antigenicity of sulfanilaamide and its metabolites using fluoroscent-labelled compounds. Xenobiotica, 35: 911925, 2005.

Toda A, Eyanagi R, Saito H, Soeda S, Shimeno H, Moriyama M, Shigematsu H.: Effects of experimental diabetes on hepatic drug metabolism in rats: the activities of flavin-containing monooxygenase, the phase II conjugation reactions and glutathione related enzymes. Res. Commun. Mol. Pathol. Pharmacol., 117: 13-27, 2005.





Kozako T, Suzuki S, Yoshimitsu M, Arima N, Honda S-I, Soeda S
Anticancer agents targeted to sirtuins
Molecules, 19:20295-20313, 2014

Kozako T, Arima N, Yoshimitsu M, Honda SI, Soeda S.
Liposomes and nanotechnology in drug development: focus on oncotargets
Int J Nanomedicine, 7: 4943-4951, 2012.

Misasi R, Hozumi I, Inuzuka T, Capozzi A, Mattei V, Kuramoto Y, Shimeno H, Soeda S, Azuma N, Yamauchi T, Hiraiwa M.: Biochemistry and Neurobiology of Prosaposin: a potential therapeutic neuro-effector. Current Nervous System Agents in Medicinal Chemistry, 2: 119-131, 2009.

Soeda S, Koyanagi S, Kuramoto Y, Kimura M, Oda M, Kozako T, Hayashida S, Shimeno H.: Anti-apoptotic roles of plasminogen activator inhibitor-1 as a neurotrophic factor in the central nervous system. Thromb. Haemost., 100: 1014-1020, 2008.

Soeda S, Sakata A, Ochiai T, Yasuda K, Kuramoto Y, Shimeno H, Toda A, Eyanagi R, Hikishima S, Yokamatsu T, Shibuya S.: Sphingomyelinase inhibition suggests a possible new strategy for the treatment of inflammatory bowel disease. Current Drug Therapy, 3: 218-225, 2008.

Soeda S, Ochiai T, Shimeno H, Saito H, Abe K, Tanaka H, Shoyama Y.: Pharmacological activities of crocin in saffron. J. Nat. Med., 61: 102-111, 2007.




Nobuhiro Harada and Shin-ichiro Honda.,
Molecular Mechanisms Controlling Brain Aromatase Expression

Makoto Yoshimitsu, Tomohiro Kozako and Naomichi Arima
Prevention of Human T-Cell Lymphotropic Virus Infection and Adult T-Cell Leukemia
T-Cell Leukemia - Characteristics, Treatment and Prevention (ISBN 980-953-307-735-7), InTech, 2012.

Tomohiro Kozako, Shinya Hirata, Makoto Yoshimitsu, and Naomichi Arima
Prophylactic and Therapeutic Approach for Adult T-cell Leukemia Based on Targeting Anti-tumor Immunity.
Major Histocompatibility Complex: Biology, Functions and Roles in Disease
Nova Science Publishers, Inc., NY (2011).

Soeda S, Koyanagi S, Shimeno H.: Chapter 32. Marine polysaccharides and angiogenesis: modulation of angiogenesis by fucoidans. In Anti-Angiogenic Functional and Medicinal Foods (eds. by Losso JN, Shahidi F, Bagchi D), Pp 651-671, CRC Press, NY (2007).

Soeda S, Ochiai T, Tanaka H, Shoyama Y, Shimeno H. : Chapter V. Prevention of ischemic neuron death by a saffron’s carotenoid pigment crocin and its mechanism of action. In Focus on Neurochemistry Research (ed. by R.T. Coleman), Pp 139156, Nova Science Publishers, Inc., NY (2005).

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