論文発表(原著論文、総説)

現時点(2015)でのインパクトファクター上位論文掲載履歴

  掲載論文名 Impact F. 掲載回数
1 Science 31.477 1
2 Molecular Psychiatry 15.147 1
3 J Clinical Investigation 13.765 1
4 Nature Communications 10.742 1
5 Proc Natl Acad Sci USA 9.681 3
6 Stem Cells 7.133 1
7 Human Molecular Genetics 6.677 1
8 Stroke 6.018 3
9 J Cereb Blood Flow Metab 5.339 3
10 J Biol Chem 4.600 2
11 J Neurochem 4.244 5
12 PLoS One 3.534 2
IPはトムソン・ロイター2014版による
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2017年   

  1. Astrocytes with previous chronic exposure to amyloid β-peptide fragment 1–40 suppress excitatory synaptic transmission.Kawano H, Oyabu K, Yamamoto H, Eto K, Adaniya Y, Kubota K, Watanabe T, Hirano-Iwata A, Nabekura J, Katsurabayasi S, Iwasaki K.,  J Neurochemistry, 2017
  2. Role of vasopressin V1a receptor in delta9-tetrahydrocannabinol-induced cataleptic immobilization in mice. Egashira N, Koushi E, Myose T, Tanoue A, Mishima K, Tsuchihashi R, Kinjo J, Tanaka H, Morimoto S, Iwasaki K.,Psychopharmacology(Berl), DOI10.1007/s00213-017-4735-1, 2017
  3. アリピプラゾール錠・OD錠・散・内服液「ニプロ」のマウスを用いた抗精神病効果の検討,長尾昌紀、森山博史、大藪康平、安谷屋友菜、胸元 芳、渡辺拓也、岩崎克典, 新薬と臨床 66:611-620, 2017
  4. Effect of hachimijiogan on memory impairment induced by beta-amyloid combined with cerebral ischemia in rats, Hiroshi Moriyama, Takayasu Mishima, Mosaburo Kainuma, Takuya Watanabe, Masaki Nagao, Kotaro Takasaki, Kaori Kubota, Shutaro Katsurabayashi, Yoshio Tsuboi, Katsunori Iwasaki, Traditional & Kampo Medicine vol.4:51-54,2017
  5. Ameliorative effect of sansoninto on sleep disturbance and spatial memory impairment in an Alzheimer's disease rat model, Hiroshi Moriyama, Takuya Watanabe, Kotaro Takasaki, Masaki Nagao, Kaori Kubota, Shutaro Katsurabayashi, Nobuaki Egashira, Katsunori Iwasaki, Traditional & Kampo Medicine vol.4:38-45,2017
  6. BPSDに対する抑肝散加陳皮半夏の基礎と臨床応用、岩崎克典 Science of Kampo Medicine 漢方医学 vol/41(1):38-42, 2017
2016年
  1. Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats. Egashira N, Iba H, Kuwano H, Kawanaka R, Nagao M, Moriyama H, Watanabe T, Kubota K, Katsurabayashi S, Iwasaki K., J. Pharmacol. Sci. 131:279-283, 2016
  2. Unidirectional signal propagation in primary neurons micropatterned at a single-cell resolution, Yamano H., Matsumura R., Takaoki H., Katsurabayashi S., Hirano-Iwata A., and Niwano M., Applied Physics Letters, 109/043703, 1-5. 2016
  3. アルツハイマー型認知症モデルラットの空間認知障害に対するドネペジルと抑肝散の併用効果、角田菜緒, 長尾昌紀, 森山博史, 呼和哈斯, 古賀冴華, 窪田香織, 渡辺拓也, 桂林秀太郎, 岩崎克典、臨牀と研究 93(12): 1659 -1660 2016
  4. 神経栄養因子の補充療法に替わる抑肝散による認知症治療法の構築、窪田香織、渡辺拓也、桂林秀太郎、岩崎克典、BIO Clinica, 31(4), 87-92(2016)
  5. 認知症新規治療薬を目指した八味地黄丸の神経栄養因子様作用の解析、福江悠香, 佐藤瞳, 窪田香織, 桂林秀太郎, 江頭伸昭, 貝沼茂三郎, 岩崎克典、臨牀と研究 93(12): 1657 -1659 2016
  6. Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission.Katsurabayashi S, Kawano H, Ii M, Nakano S, Tatsumi T, Kubota K, Takasaki K, Mishima K, Fujiwara M, Iwasaki K. Physiol Rep, 4 (1), e12665, doi: 10.14814/phy2.12665(2016)
2015年
  1. 鼎談 漢方の臨床と薬理 精神神経科領域における漢方薬の臨床と薬理、岩崎克典、漢方医薬学雑誌、23(3): 4-12 (2015)
  2. 抑肝散のセロトニン神経系とグルタミン酸神経系を介した作用、岩崎克典、漢方医薬学雑誌、23(3):13-14 (2015)
  3. 漢方薬の薬理作用 抑肝散佳陳皮半夏、岩崎克典、長尾昌紀、森山博史、脳21 18(4):305 -312 (2015)
  4. Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture. Esteves da Silva M, Adrian M, Schätzle P, Lipka J, Watanabe T, Cho S, Futai K, Wierenga CJ, Kapitein LC, Hoogenraad CC. Cell Rep. 13/5, 933-43( 2015)
  5. Rheb activation disrupts spine synapse formation through accumlation of syntenin in tuberous sclerosis complex.Sugiura H, Yasuda S, Katsurabayashi S, Kawano H, Endo K, Takasaki K, Iwasaki K, Ichikawa M, Kobayashi T, Hino O, Yamagata K. Nat Commun6, 6842 (2015)
  6. Ganglioside GM3 is essential for the structural integrity and function of cochlear hair cells.Yoshikawa M, Go S, Suzuki SI, Suzuki A, Katori Y, Morlet T, Gottlieb SM, Fujuwara M, Iwasaki K, Strauss KA, Inokuchi JI. Hum Mol Genet. 24(10), 2796-807 (2015)
  7. Mouse model of subarachnoid hemorrhage: technical note on the filament perforation model.Muroi C, Fujioka M, Marbacher S, Fandino J, Keller E, Iwasaki K, Mishima K.Acta Neurochir Suppl.,120:315-20 (2015)
  8. Clinical Effect of Gargling Loperamide Liquid for Oral Mucositis Caused by Cancer Chemotherapy, Kaneko T, Nagamatsu M, Inoue R, Mishima K, Iwasaki K, Kamimura H. Jpn. Pharmacol. Ther. 22/1,69-77  (2015)
  9. Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons. Mao W, Watanabe T, Cho S, Frost JL, Truong T, Zhao X, Futai K. Eur J Neurosci.,  41/8, 1025-35(2015)
2014年
  1. Effect of Yokukansan on sleep disturbance in a rat model of cerebrovascular dementia. Nagao M,Takasaki K, Nogami A, Hirai Y, Moriyama H, Uchida H, Kubota K, Katsurabayashi S, Mishima K, Nishimura R and Iwasaki K. Traditional & Kampo Medicine ,  1/2,19-26 , (2014)
  2. 八味地黄丸の空間記憶障害に対する改善作用. 高崎浩太郎、窪田 香織、岩崎克典  Research19/4,27-28, (2014)
  3. Clinical effects of gargling loperamide liquid for oral mucositis caused by cancer chemotherapy. Kaneko T, Inoue R, Mishima K, Iwasaki K, Kamimura H. Jpn Pharmacol There42/11,851-855 (2014)
  4. アルツハイマー病新規治療戦略を指向した異常老化アストロサイトに関する研究.河野洋幸、桂林秀太郎、窪田香織、高崎浩太郎、三島健一、藤原道弘、岩崎克典  臨床と研究, 91/11,126-127(2014)
  5. 脳血管性障害に対する血液凝固制御因子ADAMTS13の脳保護効果.中野貴文、入江圭一、三島健一、二神幸次郎、岩崎克典  臨床と研究, 91/11,127-127(2014)
  6. 脳由来神経栄養因子の発現誘導作用を介した抑肝散のアルツハイマー病モデル動物の不安様行動に対する効果.高尾優那, 野上 愛、高崎浩太郎、窪田香織、山下 拓、山本香織、松原友里香、内田直樹、桂林秀太郎、三島健一、藤原道弘、西村良二、岩崎克典  臨床と研究 , 91/11,128-128(2014)
  7. 脳高次機能と漢方.岩崎克典  脳21, 17/4,97-104(2014)
  8. Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.Yasuda S, Sugiura H, Katsurabayashi S, Shimada T, Tanaka H, Takasaki K, Iwasaki K, Kobayashi T, Hino O, Yamagata K.  Sci Rep., 4/,51-55(2014)
  9. Filament perforation model for mouse subarachnoid hemorrhage: surgical-technical considerations.Muroi C, Fujioka M, Okuchi K, Fandino J, Keller E, Sakamoto Y, Mishima K, Iwasaki K, Fujiwara M.  Br J Neurosurg.,19/1-11(2014)
  10. 抑肝散の認知症症状に対する薬理学的検討.窪田香織、野上 愛、高崎浩太郎、桂林秀太郎、三島健一、藤原道弘、岩崎克典  日本薬理学雑誌 ,  143/3,110-115(2014)
  11. Pharmacological study of the amerliorative effects of Yokukansan on memory impairment and the behavioral and psychological symptoms of dementia in AD models. Kubota K, Nogami A, Takasaki K, Katsurabayashi S, Mishima K, Fujiwara M, Iwasaki K. Nihon Yakurigaku Zasshi. 2014 Mar;143(3):110-114 (2014)
  12. Effect of ADAMTS13 on Cerebrovascular Microthrombosis and Neuronal Injury after Experimental Subarachnoid Hemorrhage.Muroi C, Fujioka M, Mishima K, Irie K, Fujimura Y, Nakano T, Fandino J, Keller E, Iwasaki K, Fujiwara M.  J Thromb Haemost.,(2014)
  13. グラム陽性球菌感染症に対するDaptomycinの有効性・安全性の評価. 中野貴文,宮崎元康,戸川 温,高田 徹,三島健一,岩崎克典,二神幸次郎, 医療薬学,40(3),(2014)
2013年
  1. Effect of Yokukansan on memory disturbance in an animal model of cerebrovascular dementia, Nogami A, Takasaki K, Kubota K, Yamaguchi K, Kawasaki C, Nakamura K, Fujikawa R, Uchida N, Katsurabayashi S, Mishima K, Nishimura R, Fujiwara M, Iwasaki K, J. Trad. Med. 30: in press  (2013)
  2. 白金錯体系抗悪性腫瘍剤のオキサリプラチンによる末梢神経障害に対する加工ブシの軽減効果, 松尾 宏一、入江 圭一、林 稔展、市丸 優希、白川 敦規、長谷川 恭子、大津 加也、原 暦、倉成 沙織、山下 郁太、三島 健一、岩崎 克典、藤原 道弘 , 漢方と最新治療,  22/3, 243-250 (2013)
  3. A human Dravet syndrome model from patient induced pluripotent stem cells. , Higurashi N, Uchida T, Christoph L, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori MX, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S. Molecular Brain, 6/1, 19 (2013)
  4. Yokukansan, a traditional Japanese herbal medicine, promotes neurite out grought in PC12 cells through the activation of extracellular signal regulated kinase 1/2 and phosphatidylinositol 3-kinase/Akt. Kubota K, Sano K, Shiraishi A, Beppu N, Uchida N, Takasaki K, Katsurabayashi S, Mishima K, Nishimura R, Fujiwara M, Iwasaki K. J Trad. Med. 30:102-113 (2013)
  5. Allogeneic Transplantation of Fetal Membrane-Derived Mesenchymal Stem Cell Sheets Increases Neovascularization and Improves Cardiac Function after Myocardial Infarction in Rats., Ishikane S, Hosoda H, Yamahara K, Akitake Y, Kyoungsook J, Mishima K, Iwasaki K, Fujiwara M, Miyazato M, Kangawa K, Ikeda T. Transplantation. 96(8):697-706 (2013)
  6. クエチアピンフマル酸塩錠(クエチアピン錠「NP」およびセロクエル錠)の実験的統合失調症モデルマウスにおける行動薬理作用の比較, 野上 愛、高崎浩太郎、長尾昌紀、坂元佑哉、窪田香織、桂林秀太郎、三島健一、岩崎克典, 新薬と臨床62(1), 13-20(2013)
  7. 認知症の予防・治療に応用可能な漢方薬・抑肝散の薬理学的検討窪田香織、高崎浩太郎、野上愛、岩崎克典、福岡大学研究推進部ニュース&レポートReserch, 18(2), 19-22 (2013)
  8. Effects of mood stabilizers on marble-burying behavior in mice, Egashira N, Abe M, Shirakawa A, Niki T, Mishima K, Iwasaki K, Oishi R, Fujiwara M. Psychopharmacology, 226(2): 295-235(2013)
  9. Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden. Watanabe T, Takasaki K, Yamagata N, Fujiwara M, Iwasaki K. Neurosci Lett.536: 74-79(2013)
  10. Injection of specific amyloid-beta oligomers (beta1-40:beta1-42=10:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis. Ozdemir MB, Erdogan C, Iwasaki K, Watanabe T, Ishikane S, Fujiwara M. Neurol Res. 2013 Oct;35(8):798-803
  11. Cholinergic Involvement and Synaptic Dynamin 1 Expression in Yokukansan-mediated Improvement of Spatial Memory in a Rat Model of Early Alzheimer's Disease. Uchida N, Takasaki K, Sakata Y, Nogami A, Oishi H, Watanabe T, Shindo T, Egashira N, Kubota K, Katsurabayashi S, Mishima K, Fujiwara M, Nishimura R, Iwasaki K. Phytother Res.27(7) 966-972(2013)
  12. Correlation among systemic inflammatory parameter, occurrence of delayed neurological deficits, and outcome after aneurysmal subarachnoid hemorrhage. Muroi C, Hugelshofer M, Seule M, Tastan I, Fujioka M, Mishima K, Keller E. Neurosurgery. Oct;73(4):E753.n(2013)

2012年

  1. Preferential involvement of Na+/Ca2+ exchanger type-1 in the brain damage caused by transient focal   ischemia in mice. Morimoton, Kita S, Shimazawa M, Namimatsu H, Tsuruma K, Hayakawa K, Mishima K, Egashira N, Iyoda T,  Horie I, Gotoh Y,  Iwasaki K,  Fujiwara M, Matsuda T,  Baba A,  Komuro I,  Horie K,  Takeda J,  Iwamoto T, Hara H, Biochemical and Biophysical Research Communications. (2012) accepted
  2. Long-Term Culture of Astrocytes Attenuates the Readily Releasable Pool of Synaptic Vesicles. Kawano H, Katsurabayashi S, Kakazu Y, Yamashita Y, Kubo N, Kubo M, Okuda H, Takasaki K, Kubota K, Mishima K, Fujiwara M, Harata NC and Iwasaki K. PLoS One,7(10):e48034.2012
  3. Effects of mood stabilizers on marble-burying behavior in mice. Egashira N, Abe M, Shirakawa A, Niki T, Mishima K, Iwasaki K, Oishi R, Fujiwara M. Psychopharmacology, (2012) accepted
  4. Cholinergic Involvement and Synaptic Dynamin 1 Expression in Yokukansan-mediated Improvement of Spatial Memory in a Rat Model of Early Alzheimer's Disease.Uchida N, Takasaki K, Sakata Y, Nogami A, Oishi H, Watanabe T, Shindo T, Egashira N, Kubota K, Katsurabayashi S, Mishima K, Fujiwara M, Nishimura R, Iwasaki K. Phytother Res. 2012 Aug 11. doi: 10.1002/ptr.4818.
  5. Pharmacological studies for the ameliorative effects of yokukansan on memory deficits and abnormal behavior in an animal model of dementia.Iwasaki K, Takasaki K, Nogami A, Kubota K, Katsurabayashi S, Mishima K, Fujiwara M. 抑肝散の認知症に対する治療効果の行動薬理学的実証、 岩崎克典、高崎浩太郎、野上 愛、窪田香織、桂林秀太郎、三島健一、藤原道弘, 日本薬理学雑誌, 140/2,66-70, (2012)
  6. ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury. Fujioka M, Nakano T, Hayakawa K, Irie K, Akitake Y, Sakamoto Y, Mishima K, Muroi C, Yonekawa Y, Banno F, Kokame K, Miyata T, Nishio K, Okuchi K, Iwasaki K, Fujiwara M, Siesjö BK. Neurol Sci, 33(5), 1107-1115 (2012)
  7. N-Acetyl-L-Cysteine inhibits Marble-burying behavior in mice. Egashira N, Shirakawa A, Abe M, Niki T, Mishima K, Iwasaki K, Oishi R, Fujiwara M.  J Pharmacol Sci, 119, 97-101 (2012)
  8. Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. Higuchi S, Irie K, Yamaguchi R, Katsuki M, Araki M, Ohji M, Hayakawa K, Mishima S, Akitake Y, Matsuyama K, Mishima K, Mishima K, Iwasaki K, Fujiwara M. PLos One, 7(6):e38609. 2012
  9. Influence of Telmisartan as a PPARγ Partial Agonist on Neuronal Cell-death and Memory Impairment Induced by Cerebral Ischemia in Rats. Iwasaki K, Takasaki K, Haraguchi T, Kubota K, Katsurabayashi S, Mishima K, and Fujiwara M. Therapeutic Research, 33(5):685-693, 2012
  10. Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer's disease incorporating additional cerebrovascular disease factors. Shindo T, Takasaki K, Uchida K, Onimura R, Kubota K, Uchida N, Irie K, Katsurabayashi S, Mishima K, Nishimura R, Fujiwara M, Iwasaki K. Biol Pharm Bull.35(12), 2141-2147(2012)
  11. ドネペジル塩酸塩OD錠「NO」のアルツハイマー病モデルラットの空間記憶障害に対する改善作用、野上 愛、高崎浩太郎、長尾昌紀、坂元佑哉、窪田香織、桂林秀太郎、三島健一、岩崎克典、J New Rem & Clin, 新薬と臨床vol.61,No.3, 55-61, 2012
  12. Role of 5-hydroxytryptamine2C receptors in marble-burying behavior in mice. Egashira N, Okuno R, Shirakawa A, Nagao M, Mishima K, Iwasaki K, Oishi R, Fujiwara M. Biol.Pharm.Bull.35(3):376-379, 2012
  13. CD4 and CD8 Tcells require different membrane ganglioside for activation.Nagafuku M, Okuyama K, Onimaru Y, Suzuki A, Odagiri Y, Yamashita T, Iwasaki K, Fujiwara M, Takayanagi M, Ohno I, Inokuchi J, Proc Natl Acad Sci USA, 109(6) :330-342, 2012
  14. Involvement of opioid system in cognitive deficits induced by ∆9-tetrahydrocannabinol in rats. Egashira N, Manome N, Mishima K, Iwasaki K, Oishi R, Fujiwara M.  Psychopharmacology (Berl), 219(4): 1111-1118,2012
  15. Magnesium and the inflammatory response: potential pathophysiological implications in the management of patients with aneurysmal subarachnoid hemorrhage? Muroi C, Burkhardt JK, Hugelshofer M, Seule M, Mishima K, Keller E. Magnes Res. Jul;25(2):64-71. 2012
  16. Novel treatments for vasospasm after subarachnoid hemorrhage.Muroi C, Seule M, Mishima K, Keller E. Curr Opin Crit Care. 18(2):119-26.2012
  17. Transparent polymeric hybrid film of ZnO nanoparticle quantum dots and PMMA with high luminescence and tunable emission color.Matsuyama K, Mishima K, Kato T, Irie K, Mishima K.J Colloid Interface Sci. 367(1):171-177. 2012
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2011年

  1. Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABA(A) - Benzodiazepine Receptor Complex. Egashira N, Nogami A, Iwasaki K, Ishibashi A, Uchida N, Takasaki K, Mishima K, Nishimura R, Oishi R, Fujiwara M. J Pharmacol Sci., 116(3): 316-320, 2011
  2. Neuroprotective Effects of Citidine-5-diphosphocholine on Impaired Spatial Memory in a Rat Model of Cerebrovascular Dementia. Takasaki K, Uchida K, Fujikawa R, Nogami A, Nakamura K, Kawasaki C, Yamaguchi K, Morita M, Morishita K, Kubota K, Katsurabayashi S, Mishima K, Fujiwara M, Iwasaki K. J Pharmacol Sci.,116(2):232-237, 2011
  3. Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice.Egashira N, Shirakawa A, Okuno R, Mishima K, Iwasaki K, Oishi R, Fujiwara M. Pharmacol.Biochem. Behav. 99:52-58, 2011
  4. Effects of yokukansan on anxiety-like behavior in a rat model of cerebrovascular dementia.Nogami A, Sakata Y, Uchida N, Yamaguchi K, Kawasaki C, Shindo T, Kubota K, Katsurabayashi S, Takasaki K, Mishima K, Nishimura R, Fujiwara M, Iwasaki K. J Nat Med, 65:275-281, 2011
  5. Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors.Higuchi S, Ohji M, Araki M, Furuta R, Katsuki M, Yamaguchi R, Akitake Y, Matsuyama K, Irie K, Mishima K, Mishima K, Iwasaki K, Fujiwara M. Behav Brain Res., 216(1):477-480, 2011
  6. 幼若期におけるGABA応答は興奮性か抑制性か? 桂林秀太郎, 日本薬学会誌ファルマシア、47, 861-862 (2011)
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2010年

  1. Neuroprotective effect of repeated treatment with Hericium Erinaceum in mice subjected to middle cerebral artery occlusion. Hazekawa M, Kataoka A, Hayakawa K, Uchimasu T, Furuta R, Irie K, Akitake Y, Yoshida M, Fujioka T, Egashira N, Oishi R, Mishima K, Mishima K, Uchida T, Iwasaki K, Fujiwara M. J Health Science, 56(3):296-303, 2010
  2. Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats. Ishikane S, Yamahara K, Sada M, Harada K, Kodama M, Ishibashi-Ueda H, Hayakawa K, Mishima K, Iwasaki K, Fujiwara M, Kangawa K, Ikeda T. J Mol Cell Cardiol., 49(5):753-761, 2010
  3. Analysis of a case of oxaliplatin - induced persistence sensory neuropathy. Matsuo K, Higuchi M, Sasaki Y, Iwatsubo S, Wada Y, Hasegawa K, Shirakawa A, Mishima K, Iwasaki K, Fujiwara M, Nishino H. Jpn J Cancer and Chemotherapy, 37(3): 551-554, 2010
  4. The Cannabinoid 1-Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice. Higuchi S, Irie K, Mishima S, Araki M, Ohji M, Shirakawa A, Akitake Y, Matsuyama K, Mishima K, Mishima K, Iwasaki K, Fujiwara M. J Pharmacol Sci. 112(3):369-372, 2010
  5. Ameliorating effects of Kangen-karyu on neuronal damage in rats subjected to repeated cerebral ischemia. Pu F, Kaneko T, Enoki M, Irie K, Okamoto T, Sei Y, Egashira N, Oishi R, Mishima K, Kamimura H, Iwasaki K, Fujiwara M. J Nat Med. 64(2):167-174, 2010
  6. Dynamin 1 depletion and memory deficits in rats treated with A-beta and cerebral ischemia. Watanabe T, Iwasaki K, Takasaki K, Yamagata N, Fujino M, Nogami A, Ii M, Katsurabayashi S, Mishima K, Fujiwara M. J.Neurosci.Res. 88(9):1908-1917, 2010
  7. Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice. Tajima O, Egashira N, Ohmi Y, Fukue Y, Mishima K, Iwasaki K, Fujiwara M, Sugiura Y, Furukawa K, Furukawa K. Behav Brain Res., 206(1):101-108, 2010
  8. Reducing Acyl Migration during Purification of 2-Arachidonoylglycerol from Biological Samples before Gas Chromatography Mass Spectrometry Analysis. Higuchi S, Irie K, Nakano T, Sakamoto Y, Akitake Y, Araki M, Ohji M, Furuta R, Katsuki M, Yamaguchi R, Matsuyama K, Mishima K, Mishima K, Iwasaki K, Fujiwara M. Anal. Sci., 26(11): 1199-1202, 2010
  9. Telmisartan, a partial agonist of peroxisome proliferator-activated receptor gamma, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia. Haraguchi T, Iwasaki K, Takasaki K, Uchida K, Naito T, Nogami A, Kubota K, Shindo T, Uchida N, Katsurabayashi S, Mishima K, Nishimura R, Fujiwara M. Brain Research, 1353:125-132, 201
  10. Depression-like behavior and reduced plasma testosterone levels in the senescence-accelerated mouse.Egashira N, Koushi E, Okuno R, Shirakawa A, Mishima K, Iwasaki K, Oishi R, Fujiwara M. Behav Brain Res. 209(1):142-147, 2010
  11. Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice. Hayakawa K, Nakano T, Irie K, Higuchi S, Fujioka M, Orito K, Iwasaki K, Jin G, Lo EH, Mishima K, Fujiwara M. J Cereb Blood Flow Metab., 30(4):871-882, 2010
  12. Neuroprotective effect of repeated treatment with Hericium Erinaceum in mice subjected to middle cerebral artery occlusion. Hazekawa M, Kataoka A, Hayakawa K, Uchimasu T, Furuta R, Irie K, Akitake Y, Yoshida M, Fujioka T, Egashira N, Oishi R, Mishima K, Mishima K, Uchida T, Iwasaki K, Fujiwara M. J Health Sciences, 56(3):296-303, 2010
  13. Analysis of a case of oxaliplatin - induced persistence sensory neuropathy. Matsuo K, Higuchi M, Sasaki Y, Iwatsubo S, Wada Y, Hasegawa K, Shirakawa A, Mishima K, Iwasaki K, Fujiwara M, Nishino H.癌と化学療法,37(3):551-554,2010, Mar.
  14. 大麻の乱用防止教育と高等学校教諭の意識に関する研究, 松本禎明, 江頭伸昭、坂井留美、岩崎克典、三島健一、藤原道弘, 九州女子大学紀要 46(2):131-150, 2010,Jan
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2009年

  1. Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress. Sano K, Koushi E, Irie K, Higuchi S, Tsuchihashi R, Kinjo J, Egashira N, Oishi R, Uchida N, Nagai H, Nishimura R, Tanaka H, Morimoto S, Mishima K, Iwasaki K, Fujiwara M. Biol Pharm Bull.32:2065-2067,2009
  2. 抑肝散のセロトニン2A受容体を介した作用, 野上 愛、高崎浩太郎、岩崎克典、藤原道弘 脳21:12(4),30-34,2009
  3. Role of vasopressin receptor in psychological and cognitive functions, Egashira N, Mishima K, Iwasaki K, Nakanishi H, Oishi R, Fujiwara M. Nippon Yakurigaku Zasshi. 2009 Jul;134(1):3-7.
  4. Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti. Yoshikawa M, Go S, Takasaki K, Kakazu Y, Ohashi M, Nagafuku M, Kabayama K, Sekimoto J, Suzuki S, Takaiwa K, Kimitsuki T, Matsumoto N, Komune S, Kamei D, Saito M, Fujiwara M, Iwasaki K, Inokuchi J., Proc Natl Acad Sci U S A.;106(23):9483-8. 2009 Jun 9
  5. Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor gamma-dependent mechanism. Haraguchi T, Takasaki K, Naito T, Hayakawa K, Katsurabayashi S, Mishima K, Iwasaki K, Fujiwara M. Neurosci Lett. 464(3):151-5. 2009 Oct.
  6. Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism. Hayakawa K, Irie K, Sano K, Watanabe T, Higuchi S, Enoki M, Nakano T,Harada K, Ishikane S, Ikeda T, Fujioka M, Orito K, Iwasaki K, Mishima K,Fujiwara M. Biol Pharm Bull.;32(9):1538-44. 2009 Sep
  7. Neuroprotective effects of Kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats. Pu F, Motohashi K, Kaneko T, Tanaka Y, Manome N, Irie K, Takata J, Egashira N, Oishi R, Okamoto T, Sei Y, Yokozawa T, Mishima K, Iwasaki K, Fujiwara M. J Pharmacol Sci. 109(3):424-30. 2009 Mar
  8. Yokukansan inhibits social isolation-induced aggression and methamphetamine-induced hyperlocomotion in rodents. Uchida N, Egashira N, Iwasaki K, Ishibashi A, Tashiro R, Nogami A, Manome N, Abe M, Takasaki K, Mishima K, Takata J, Oishi R, Nishimura R, Fujiwara M. Biol Pharm Bull. 32(3):372-5. 2009 Mar
  9. New topics in vasopressin receptors and approach to novel drugs: role of the vasopressin receptor in psychological and cognitive functions. Egashira N, Mishima K, Iwasaki K, Oishi R, Fujiwara M. J Pharmacol Sci. 109(1):44-9. 2009 Jan
  10. Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging. Tajima O, Egashira N, Ohmi Y, Fukue Y, Mishima K, Iwasaki K, Fujiwara M, Inokuchi J, Sugiura Y, Furukawa K, Furukawa K. Behav Brain Res. 198(1):74-82. 2009 Mar
  11. Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease. Watanabe T, Yamagata N, Takasaki K, Sano K, Hayakawa K, Katsurabayashi S, Egashira N, Mishima K, Iwasaki K, Fujiwara M. Brain Res. 16;1249:222-8. 2009 Jan
  12. Characteristic behavioral anomalies in rats prenatally exposed to 5-bromo-2'-deoxyuridine. Orito K, Morishima A, Ogawa T, Muneoka K, Kuwagata M, Takata J, Mishima K, Fujiwara M. Int J Dev Neurosci. 27(1):81-6. 2009 Feb
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2008年

  1. Calcium-channel antagonists inhibit marble-burying behavior in mice. Egashira N, Okuno R, Abe M, Matsushita M, Mishima K, Iwasaki K, Oishi R, Nishimura R, Matsumoto Y, Fujiwara M. J Pharmacol Sci. 108(1):140-3. 2008 Sep
  2. Allogeneic injection of fetal membrane-derived mesenchymal stem cells induces therapeutic angiogenesis in a rat model of hind limb ischemia. Ishikane S, Ohnishi S, Yamahara K, Sada M, Harada K, Mishima K, Iwasaki K, Fujiwara M, Kitamura S, Nagaya N, Ikeda T. Stem Cells. 26(10):2625-33. 2008 Oct
  3. Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms. Egashira N, Okuno R, Matsushita M, Abe M, Mishima K, Iwasaki K, Nishimura R, Oishi R, Fujiwara M. Eur J Pharmacol. 592(1-3):103-8. 2008 Sep
  4. Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism. Hayakawa K, Mishima K, Irie K, Hazekawa M, Mishima S, Fujioka M, Orito K, Egashira N, Katsurabayashi S, Takasaki K, Iwasaki K, Fujiwara M. Neuropharmacology. 55(8):1280-6. 2008 Dec
  5. Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system. Egashira N, Matsuda T, Koushi E, Higashihara F, Mishima K, Chidori S, Hasebe N, Iwasaki K, Nishimura R, Oishi R, Fujiwara M. Eur J Pharmacol. 28;589(1-3):117-21. 2008 Jul
  6. Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex. Egashira N, Iwasaki K, Ishibashi A, Hayakawa K, Okuno R, Abe M, Uchida N, Mishima K, Takasaki K, Nishimura R, Oishi R, Fujiwara M. Prog Neuropsychopharmacol Biol Psychiatry. 1;32(6):1516-20. 2008 Aug
  7. Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogs. Orito K, Saito M, Fukunaga K, Matsuo E, Takikawa S, Muto M, Mishima K, Egashira N, Fujiwara M., J Vet Pharmacol Ther. 31(3):259-64. 2008 Jun
  8. Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder. Egashira N, Okuno R, Harada S, Matsushita M, Mishima K, Iwasaki K, Nishimura R, Oishi R, Fujiwara M. Eur J Pharmacol. 31;586(1-3):164-70. 2008 May
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2007年

  1. Kamikihi-to, a Kampo medicine, Ameliorates impairment of spatial memory in rats. Egashira N, Manome N, Kurauchi K, Matsumoto Y, Iwasaki K, Mishima K, Shoyama Y, Fujiwara M.  Phytother Res. 21:126-129 (2007/Feb)
  2. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Ochiai T, Shimeno H, Mishima K, Iwasaki K, Fujiwara M, Tanaka H, Shoyama Y, Toda A, Eyanagi R, Soeda S.  Biochim Biophys Acta. 1770:578-584 (2007/Jan)
  3. High-cholesterol feeding aggravates cerebral infarction via decreasing the CB(1) receptor. Hayakawa K, Mishima K, Nozako M, Hazekawa M, Aoyama Y, Ogata A, Harada K, Fujioka M, Abe K, Egashira N, Iwasaki K, Fujiwara M.  Neurosci Lett. 414:183-187 (2007)
  4. Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice. Egashira N, Tanoue A, Matsuda T, Koushi E, Harada S, Takano Y, Tsujimoto G, Mishima K, Iwasaki K, Fujiwara M.     Behav Brain Res. 78, 123-127 (2007/Feb)
  5. Comparison of Single- and Repeated-Ischemia-Induced Changes in Expression of Flip and Flop Splice Variants of AMPA Receptor Subtypes GluR1 and GluR2 in the Rats Hippocampus CA1 Subregion. Hatip-Al-Khatib I, Iwasaki K, Egashira N, Ishibashi D, Mishima K, Fujiwara M. J Pharmacol Sci. 103(1):83-91 (2007/Jan) .
  6. Delta(9)-tetrahydrocannabinol (Delta(9)-THC) prevents cerebral infarction via  hypothalamic-independent hypothermia. Hayakawa K, Mishima K, Nozako M, Hazekawa M, Ogata A, Fujioka M, Harada K, Mishima S, Orito K, Egashira N, Iwasaki K, Fujiwara M.  Life Sci. 80, 1466-1471 (2007/March)
  7. Repeated treatment with cannabidiol but not Delta(9)-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance.  Hayakawa K, Mishima K, Nozako M, Ogata A, Hazekawa M, Liu AX, Fujioka M, Abe K, Hasebe N, Egashira N, Iwasaki K, Fujiwara M.  Neuropharmacology. 52(4), 1079-1087 (2007/March).
  8. Involvement of the sigma(1) receptor in inhibiting activity of fluvoxamine on marble-burying Egashira N, Harada S, Okuno R, Matsushita M, Nishimura R, Mishima K, Iwasaki K, Orito K, Fujiwara M.  Eur J Pharmacol. 563/1-3, 149-154,2007 /Jun
  9. Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with be-ta-anyloid in rats, Iwasaki,K., Egashira,N., Takagaki,Y., Yoshimitsu,Y., Hatip-Al-Khatib,I., Mishima,K., Fujiwara,M. Biol.Pharm.Bull. 30(4):698-701 (2007/4)
  10. Effect of Toki-shakuyaku-san on acetylcholine level and blood flow in dorsal hippocampus of intact and twice-repeated ischemic rats. Hatip-Al-Khatib I, Hatip FB, Yoshimitsu Y, Iwasaki K, Egashira N, Liu AX, Mishima K, Fujiwara M. Phytother Res.21:291-294,2007,March
  11. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. Hayakawa K, Mishima K, Nozako M, Hazekawa M, Irie K, Fujioka M, Orito K, Abe K, Hasebe N, Egashira N, Iwasaki K, Fujiwara M. J Neurochem. 102(5):1488-1496,2007,Sep
  12. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Ochiai T, Shimeno H, Mishima K, Iwasaki K, Fujiwara M, Tanaka H, Shoyama Y, Toda A, Eyanagi R, Soeda S. Biochim Biophys Acta.1770:578-584, 2007/April
  13. Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats. Pu F, Mishima K, Irie K, Motohashi K, Tanaka Y, Orito K, Egawa T, Kitamura Y, Egashira N, Iwasaki K, Fujiwara M. J Pharmacol Sci.104(4):329-334, 2007,Aug.
  14. Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. Egashira N, Hayakawa K, Osajima M, Mishima K, Iwasaki K, Oishi R, Fujiwara M. J Pharmacol Sci.105:211-214,2007/Oct
  15. Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism. Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira N, Iwasaki K, Fujiwara M. Brain Res.1188:157-164, 2007/Oct.
  16. Delta9-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats. Egashira N, Ishigami N, Mishima K, Iwasaki K, Oishi R, Fujiwara M. Prog Neuropsychopharmacol Biol Psychiatry.32:499-506, 2007/Oct.
  17. 2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice. Egashira N, Koushi E, Mishima K, Iwasaki K, Oishi R, Fujiwara M. J Pharmacol Sci.105:361-366,2007/Dec
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2006年

  1. Rehabilitative training tasks improve spatial learning impairment in the water maze following hypoxic-ischemic insult in neonatal rats. Ikeda,T., Mishima,K., Aoo,N., Harada,K., Liu,AX.,Egashira,N., Iwasaki,K., Fujiwara,M., Ikenoue,T.  Pediatr Res. 59(1):61-65 (2006/1)
  2. Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory: Involvement of 5-HT(1A) receptors in the dorsal hippocampus in rats. Egashira,N., Yano,A., Ishigami,N., Mishima,K., Iwasaki,K., Matsushita,M., Nishimura,R., Fujiwara,M. Brain Res., 1069(1)54-62(2006/1)
  3. Antagonistic effects of methanolic extract of a telephioides on morphine responses in mice. Egashira N, Li JC, Mizuki A, Yamauchi K, Matsuda T, Osajima M, Matsushita M, Mishima K, Iwasaki K, Hara S, Ono N, Nishimura R, Nohara T, Fujiwara M. J Ethnopharmacol. 104(1-2):193-198 (2006/3)
  4. Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization. Egashira N, Matsumoto Y, Mishima K, Iwasaki K, Fujioka M, Matsushita M, Shoyama Y, Nishimura R, Fujiwara M. Pharmacol Biochem Behav. 83(1):161-167 (2006/1)
  5. Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats. Iwasaki K, Egashira N, Hatip-Al-Khatib I, Akiyoshi Y, Arai T, Takagaki Y, Watanabe T, Mishima K, Fujiwara M.  Brain Res.1097(1):216-223 (2006/5)
  6. Antipsychotics improve Delta(9)-tetrahydrocannabinol-induced impairment of the prepulse inhibition of the startle reflex in mice. Nagai H, Egashira N, Sano K, Ogata A, Mizuki A, Mishima K, Iwasaki K, Shoyama Y, Nishimura R, Fujiwara M.  Pharmacol Biochem Behav. 84:330-336 (2006/6)
  7. Elevated anxiety-like and depressive behavior in Desert hedgehog knockout male mice.   Umehara F, Mishima K, Egashira N, Ogata A, Iwasaki K, Fujiwara M.  Behav Brain Res. 174(1):167-173 (2006/9).
  8. Cortical Neuronal and Glial Pathology in TgTauP301L Transgenic Mice: Neuronal Degeneration, Memory Disturbance, and Phenotypic Variation, Murakami T, Paitel E, Kawarabayashi T, Ikeda M, Chishti MA, Janus C, Matsubara E, Sasaki A, Kawarai T, Phinney AL, Harigaya Y, Horne P, Egashira N, Mishima K, Hanna A, Yang J, Iwasaki K, Takahashi M, Fujiwara M, Ishiguro K, Bergeron C, Carlson GA, Abe K, Westaway D, George-Hyslop P, Shoji M, Am J Pathol 169 (4): 1365-1375 (2006/10).
  9. Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in mice. Umeda K, Suemaru K, Todo N, Egashira N, Mishima K, Iwasaki K, Fujiwara M, Araki H. Eur J Pharmacol. 553(1-3):157-162 (2006).
  10. Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice. Egashira N, Matsuda T, Koushi E, Mishima K, Iwasaki K, Shoyama Y, Fujiwara M.  Eur J Pharmacol. 550(1-3):117-122 (2006).
  11. Effect of Toki-Shakuyaku-San on acetylcholine level and blood flow in dorsal hippocampus of intact and twice-repeated ischemic rats. Hatip-Al-Khatib I, Hatip FB, Yoshimitsu Y, Iwasaki K, Egashira N, Liu AX, Mishima K, Fujiwara M. Phytother Res. 21(3):291-294,2007,March
  12. バソプレッシン受容体欠損マウスの統合失調症モデルとしての可能性 江頭伸昭,田上昭人,辻本豪三,高野行夫,三島健一,岩崎克典,西村良二,藤原道弘 脳と精神の医学2006年 6月17巻(2) 163-168
  13. バソプレッシン受容体欠損マウスの精神疾患モデルとしての解析 江頭伸昭,田上昭人,辻本豪三,三島健一,高野行夫,岩崎克典,藤原道弘 日本神経精神薬理学雑誌 26:101-105, 2006
  14. 若齢期における大麻成分慢性投与による情報処理障害の発現 ―若齢マウスを用いたPrepulse inhibitionの検討― 永井宏,江頭伸昭,佐野和憲,緒方 歩,水木 愛,三島健一,岩崎克典,藤原道弘,西村良二 福岡大学医学紀要2006年3月第33巻(1)53-61
  15. 自然発症2型糖尿病モデルラットに対するココナッツ酵素製剤の抗糖尿病作用 江頭伸昭,淵上裕子,高垣裕紀,西田 翔,吉田 都,藤岡稔大,三島健一,岩崎克典,中村陽介,持田 肇,藤原道弘 機能性食品と薬理栄養 3: 285-290, 2006
  16. 脅迫性障害の動物モデルであるMarble-burying行動の基礎的研究松下満彦, 江頭伸昭,原田聡子,奥野良子,永井宏,千鳥正三,三島健一,岩崎克典,藤原道弘,西村良二. 福岡大学医学紀要 32(4), 159-165 (2006)
  17. 強制水泳試験における大麻成分THCの不動時間延長作用に関する研究:カンナビノイドCB1受容体の関与 千鳥正三,江頭伸昭,松田智美,合志英美,永井宏,松下満彦,内田直樹,三島健一,岩崎克典,藤原道弘,西村良二 福岡大学医学紀要2006年9月第33巻(3)197-201
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2005年

  1. Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy Jasmin I. NOOR, Tomoaki IKEDA, Kenichi MISHIMA, Naoya AOO, Sumie OHTA, Nobuaki EGASHIRA, Katsunori IWASAKI, Michihiro FUJIWARA, Tsuyomu IKENOUE Stroke 36, 2468-2474 (2005)
  2. Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice Nobuaki EGASHIRA, Katsunori IWASAKI, Akihiko TAKASHIMA, Takuya WATANABE, Hideyuki KAWABE, Tomomi MATSUDA, Kenichi MISHIMA, Shozo CHIDORI, Ryoji NISHIMURA, Michihiro FUJIWARA Brain Res. 1059, 7-12 (2005)
  3. Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder Michihiko MATSUSHITA, Nobuaki EGASHIRA, Satoko HARADA, Ryoko OKUNO, Kenichi MISHIMA, Katsunori IWASAKI, Ryoji NISHIMURA, Michihiro FUJIWARA J. Pharmacol. Sci. 99, 154-159 (2005)
  4. Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: reversal by antipsychotic drugs Nobuaki EGASHIRA, Akito TANOUE, Fuminori HIGASHIHARA, Hiroko FUCHIGAMI, Kazunori SANO, Kenichi MISHIMA, Yoshihiko FUKUE, Hiroshi NAGAI, Yukio TAKANO, Gozoh TSUJIMOTO, Jeanne STEMMELIN, Guy GRIEBEL, Katsunori IWASAKI, Tomoaki IKEDA, Ryoji NISHIMURA, Michihiro FUJIWARA Neuropsychopharmacology 30, 1996-2005 (2005)
  5. Protective effect of Toki-shakuyaku-san on amyloid s25-35-induced neuronal damage in cultured rat cortical neurons Nobuaki EGASHIRA, Katsunori IWASAKI, Yuki AKIYOSHI, Yuki TAKAGAKI, Izzettin HATIP-AL-KHATIB, Kenichi MISHIMA, Kouji KURAUCHI, Tomoaki IKEDA, Michihiro FUJIWARA Phytother. Res. 19, 450-453 (2005)
  6. Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines  levels in the ventral hippocampus of freely moving rats Izzettin HATIP-AL-KHATIB, Katsunori IWASAKI, Yoshimitsu YOSHITAKA, Takashi ARAI, Nobuaki EGASHIRA, Kenichi MISHIMA, Tomoaki IKEDA, Michihiro FUJIWARA Br. J. Pharmacol. 145, 1035-1044 (2005)
  7. Post-ischemic treatment with Toki-shakuyaku-san (Tang-Gui-Shao-Yao-San) prevents the impairment of spatial memory induced by repeated cerebral ischemia in rats Fengling PU, Kenichi MISHIMA, Nobuaki EGASHIRA, Yuki AKIYOSHI, An-Xin LIU, Kazunori SANO, Keiichi IRIE, Daisuke ISHIBASHI, Izzettin HATIP-AL-KHATIB, Kiyo IWASAKI, Kouji KURAUCHI, Katsunori IWASAKI, Michihiro FUJIWARA Am. J. Chin. Med. 33, 475-489 (2005)
  8. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism Kenichi MISHIMA, Kazuhide HAYAKAWA, Kouji ABE, Tomoaki IKEDA, Nobuaki EGASHIRA, Katsunori IWASAKI, Michihiro FUJIWARA Stroke 36, 1071-1076 (2005)
  9. Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats Shinji KATSURAGI, Tomoaki IKEDA, Isao DATE, Tetsuro SHINGO, Takao YASUHARA, Kenichi MISHIMA, Naoya AOO, Kazuhiko HARADA, Nobuaki EGASHIRA, Katsunori IWASAKI, Michihiro FUJIWARA, Tsuyomu IKENOUE Am. J. Obstet. Gynecol. 192, 1028-1037 (2005)
  10. Dexamethasone prevents long-lasting learning impairment following a combination of lipopolysaccharide and hypoxia-ischemia in neonatal rats Tomoaki IKEDA, Kenichi MISHIMA, Naoya AOO, AX LIU, Nobuaki EGASHIRA, Katsunori IWASAKI, Michihiro FUJIWARA, Tsuyomu IKENOUE Am. J. Obstet. Gynecol. 192, 719-726 (2005)
  11. 脳虚血とβ-アミロイド投与による新しいアルツハイマー病モデル動物の作成とニルバジピンの有効性 岩崎克典, 江頭伸昭, 秋吉祐樹, 高垣祐紀, 新井 隆, 三島健一, 藤原道弘 Pharma Medica 23, 143-155 (2005)
  12. Hypoxia-ischemic insult in neonatal rats induced slowly progressive brain damage related to memory impairment Kenichi MISHIMA, Tomoaki IKEDA, Naoya AOO, Nobuhiko TAKAI, Sentaro TAKAHASHI, Nobuaki EGASHIRA, Tsuyomu IKENOUE, Katsunori IWASAKI, Michihiro FUJIWARA Neurosci. Lett. 376, 194-199 (2005)
  13. 生物学的精神医学研究の現状と展望(4) 薬学部との共同による精神行動薬理学的研究ー福岡大学における取り組みを中心に 永井 宏,松下満彦,江頭伸昭,尾籠晃司,藤原道弘,西村良二 脳と精神の医学 15, 461-466 (2004)
  14. 強迫性障害の動物モデルであるMarble-burying行動の基礎的研究 松下満彦、江頭伸昭、原田聡子、奥野良子、永井 宏、千鳥正三、三島健一、岩崎克典、藤原道弘、西村良二 福岡大学医学紀要(Med.Bull.Fukuoka Univ.)32(4):159ー165,2005
  15. New perspectives in the studies on endocannabinoid and cannabis: abnormal behaviors associate with CB1 cannabinoid receptor and development of therapeutic application Michihiro FUJIWARA, Nobuaki EGASHIRA J. Pharmacol. Sci. 96, 362-366 (2004)
  16. Combination treatment of neonatal rats with hypoxia-ischemia and endotoxin induces long-lasting memory and learning impairment that is associated with extended cerebral damage Tomoaki IKEDA, Kenichi MISHIMA, Naoya AOO, Nobuaki EGASHIRA, Katsunori IWASAKI, Michihiro FUJIWARA, Tsuyomu IKENOUE Am. J. Obstet. Gynecol. 191, 2132-2141 (2004)
  17. カンナビノイドの臨床応用(著書) 藤原道弘,江頭伸昭,三島健一 Anesthesia 21 Century 7, 35-40 (2005)18.  第5章中枢神経系に作用する薬(著書) 藤原道弘 スタンダード薬学シリーズ6 薬と疾病 Ⅰ.薬の効くプロセス 90-102 東京化学同人 (2005)19.  第13章漢方処方の応用(著書) 藤原道弘,江頭伸昭 スタンダード薬学シリーズ3 化学系薬学 Ⅲ.自然が生み出す薬物 264-266 東京化学同人 (2005)
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2004年

  1. Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats. Iwasaki K, Chung E-H, Egashira N, Hatip-Al-Khatib I, Mishima K, Egawa T, Irie K, Fujiwara M, Brain Res 995, 131-139 ,(2004)
  2. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Hayakawa K, Mishima K, Abe K, Hasebe N, Takamatsu F, Yasuda H, Ikeda T, Inui K, Egashira N, Iwasaki K, Fujiwara M, Neuroreport 15, 2381-2385, (2004)
  3. Inhibition of sphingomyelinase activity helps to prenvent neuron death caused by ischemic stress. Shinji Soeda, Yoshiaki  Tsuji, Takashi Ochiai, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Tsutomu Yokomatsu, Tetsuo Murano, Shiroshi Shibuya, Hiroshi Shimeno, Neurochem., Int., 45, 619-626,  (2004)
  4. Protection by buckwheat polyphenols of cell death induced by glutamate and kainite in cultured hippocampal neurons. Pu F, Mishima K, Irie K, Egashira N, Iwasaki K, Ikeda T, Fujii H, Kosuna K, Fujiwara M, J Trad Med 21, 143-146 (2004)
  5. Determination of the effectiveness of components of herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the Scopolamine-induced impairment of rat's spatial cognition in 8-armed radial maze test. Hatip-Al-Khatib I, Egashira N, Mishima K, Iwasaki K, Iwasaki K, Kurauchi K, Inui K, Ikeda T, Fujiwara M, J Pharmacol Sci 96, 33-41 (2004)
  6. Protective effect of buckwheat polyphenols on long-lasting impairment of spatial memory associated with hippocampal neuronal damage in rats subjected to repeated cerebral ischemia. Pu F, Mishima K, Egashira N, Iwasaki K, Kaneko T, Uchida T, Irie K, Ishibashi D, Fujii H, Kosuna K, Fujiwara M, J Pharmacol Sci 94, 393-402(2004)
  7. Anandamide inhibits the DOI-induced head-twitch response in mice. Egashira N, Mishima K, Uchida T, Hasebe N, Nagai H, Mizuki A, Iwasaki K, Ishii H, Nishimura R, Shoyama Y, Fujiwara M, Psychopharmacology, 171, 382-389 (2004)
  8. Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia. Hatip-Al-Khatib I, Iwasaki K, Chung E-H, Egashira N, Mishima K, Fujiwara M, Life Sci, 75,1967-1978,(2004)
  9. Characteristics of behavioral abnormalities in α1d-adrenoceptors deficient mice. Mishima K,. Tanoue, M. Tsuda, N. Hasebe, Y. Fukue, Egashira N, Y. Takano, H. Kamiya, G. Tsujimoto, Iwasaki K, Fujiwara M, Behav Brain Res 152, 365-373 (2004)
  10. Effects  of  hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats. Mishima K, Ikeda T, Yoshikawa T, Aoo N, Egashira N, Xia YX, Ikenoue T, Iwasaki K, Fujiwara M, Behav Brain Res 151, 209-217 (2004)
  11. Neuroprotective effect of γ-glutamylethylamide (theanine) on cerebral infarction in mice. Egashira N, Hayakawa K, Mishima K, Kimura H, Iwasaki K, Fujiwara M, Neurosci Lett 363, 58-61, (2004)
  12. The serotonin1A receptor agonist 8-OH DPAT reverses △9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats. Inui K, Egashira N, Mishima K, Yano A, Matsumoto Y, Hasebe N, Abe K, Ikeda T, Iwasaki K, Fujiwara M, Neurotoxicity Res 6, 153-158 (2004)
  13. V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze. Egashira N, Tanoue A, Higashihara F, Mishima K, Fukue Y, Takano Y, Tsujimoto G, Iwasaki K, Fujiwara M, Neurosci Lett 356, 195-198 (2004)
  14. Ovariectomy  combined with  amyloid β1-42 impairs memory by decreasing acetylcholine release and α7-nAChR expression without induction of  apoptosis in the hippocampus CA1 neurons of rats. Katsunori Iwasaki, Izzettin Hatip-Al-Khatib, Nobuaki Egashira, Yuki Akiyoshi, Takashi Arai, Kenichi Mishima , Yuki Takagaki, Keiichiro Inui and Michihiro Fujiwara, Neurotoxcity Research, vol.6(4) 299-310, (2004)
  15. Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats. Hatip-Al-Khatib I, Arai T, Egashira N, Mishima K, Iwasaki K, Fujiwara M. Brain Res. 25;1012(1-2):169-76. (2004)
  16. 脳血管性痴呆症の治療薬としてのCa拮抗薬の可能性について. 岩崎克典、三島健一、江頭伸昭、藤原道弘 福岡大学薬学集報,第4巻、P61-67 (2004)
  17. 新しい遺伝子ノックダウン法, RNA interference( A new technology of knockdown, RNA interference ) 三島健一 福岡大学薬学集報,第4巻、P69-72 (2004)(18)脳虚血による記憶障害の発生機序とCa拮抗薬 岩崎克典、藤原道弘 医報フジNo.125:23-27 (2004)
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2003年

  1. Anandamide inhibits the DOI-induced head-twitch response in mice. Egashira N, Mishima K, Uchida T, Hasebe N, Nagai H, Mizuki A, Iwasaki K, Ishii H, Nishimura R, Shoyama Y, Fujiwara M.Psychopharmacology (Berl). 171:382-389,2004
  2. Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats Katsunori IWASAKI, Kenichi MISHIMA, Nobuaki EGASHIRA, Izzetin HATIP-AL-KHATIB, Daisuke ISHIBASHI, Keiichi IRIE, Hirotoshi KOBAYASHI, Takashi EGAWA, Michihiro FUJIWARA J Pharmacol Sci 93, 188-196 (2003)
  3. Local administration of glial cell line-derived neurotrophic factor improves behavioral and histological deficit of neonatal Erb's palsy in rats Hidenobu OCHIAI, Tomoaki IKEDA, Kenichi MISHIMA, Naoya AOO, Katsunori IWASAKI, Michihiro FUJIWARA, Shinichi NAKANO, Tsuyomu IKENOUE, Shinichiro WAKISAKA Neurosurgery 53, 973-978 (2003)
  4. Magnetic resonance imaging shows delayed ischemic striatal neurodegeneration M. Fujioka, T. Taoka, Y. Matsuo, K. Mishima, K. Ogoshi, Y. Kondo, M. Tsuda, M. Fujiwara, T. Asano, T. Sakaki, A. Miyasaki, D. Park, B. K. Siesjo Ann Neurol 54 732-747 (2003)
  5. How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus? Mitsuko Okada, Hiroshi Nakanishi, Toshiaki Amamoto, Ryuji Urae, Sususmu Ando, Kazuyoshi Yazawa, Michihiro Fujiwara. Brain Res., Mol. Brain Res. 111,175-181,2003
  6. Post-ischemic administration but not pre-ischemic administration of NG-nitro-L-arginie prevents spatial memory impairmentrs and apoptosis by an inhibition of a delayed increase in NOx- inthe hippocampus following repeated cerebral ischemia K.Mishima, F.Pu, T.Kaneko, E.Egashira, K.Iwasaki, M.Fujiwara Neuropharmacology,44:533-540, 2003
  7. Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairment of spatial memory in the eight-arm radial maze K.Mishima, H.Tsukikawa, I.Miura, K.Inada, K.Abe, Y.Matsumoto, N.Egashira, K.Iwasaki, M.Fujiwara Neuropharmacology, 44:541-522, 2003
  8. A synthetic ceramide analog ameliorates spatial cognition deficit and stimulates biosynthesis of brain ganglioside in rats eith cerebral ischemia Kiwamu Yamagishi, Kenichi Mishima, Yusuke Ohgami, Katusnori Iwasaki, Masayuki Jimbo, Hiroyuki Masuda, Yasuyuki Igarashi, Jin-ichi Inokuchi, Michihiro Fujiwara Eur.J.Pharmacol. 46:253-60, 2003
  9. Osteopeterosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice Tomoaki Kaifu, Jin Nakahara, Masanori Inui, Kenichi Mishima, Toshihiko Moriyama, Mitsuji Kaji, Akiko Sugahara, Hisami Koito, Azusa Ujike-Asai, Akira Nakamura, Kiyoshi Kanazawa, Kyoko Tan-Takeuchi, Katsunori Iwasaki, Wayne M.Yokohama, Akira Kudo, Michihiro Fujiwara, Hiroaki Asou, and Toshiyuki Takai J.Clinical Investigation 111: 323-332,2003
  10. Vitamin E isoforms α-tocotrienol and γ-tocotrienol prevent cerebral infarction in mice Mishima K, Tanaka T, Pu F, Egasira N, Iwasaki K, Hidaka R, Matsunaga K, Takata J, Karube Y, Fujiwara M Neuroscience Lett., 337: 56-60,, 2003
  11. Theophylline製剤服薬中に血清K+低下がみられた一症例 江川 孝、甲木敬二、松本文行、原田英徳、池堂ゆかり、山内淳史、高比良誠也、江頭伸昭、片岡泰文、藤原道弘 九州薬学会会報 57、81-86,2003
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2002年

  1. Developement of a novel experimental rat model for neonatal pre-ganglionic upper brachial plexus injury Ochiai H, Ikeda T, Mishima K, Yoshikawa T, Aoo N, Iwasaki K, Fujiwara M, Ikenoue T, Nakano S, Wakisaka S J. Neurosci. Methods, 119: 51-57, 2002
  2. Hypoxia enhances β-amiloid-induced apoptosis in rat cultured hippocampal neurons Nobuaki Egashira, Katsunori Iwasaki, Motoki Ishibashi, Izzetin Hatip-Al-Khatib, Benjamin Wolozin, Kenichi Mishima, Keiichi Irie, Michihiro Fujiwara Japan.J.Pharmacol, 90: 321-327, 2002
  3. Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau Yoshitaka Tatebayashi, Tomohiro Miyasaka, De-Hua Chui, Takumi Akagi, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Kentaro Tanemura, Miyuki Murayama, Koichi Ishiguro, Emmanuel Planei, Shinji Sato, Tsutomu Hashikawa, amd Akihiko Takashima Proc.Natl.Acad.Sci.,vol.99,No.21:13896-13901, 2002
  4. Involvement of 5-hydroxytryptamine neuronal system in delta9-tetrahydorocannabinol-induced impairment of spatial memory Nobuaki Egashira, Kenichi Mishima, Shutaro Katsurabayashi, Tomohiro Yoshitake, Yoshiaki Matsumoto, Junichi Ishida, Masatoshi Yamaguchi, Katsunori Iwasaki, Michihiro Fujiwara. Eur.J.Pharmacol., 445(3): 221-229, 2002
  5. Intracerebral microinjections of △9-tetrahydrocannabinol: search for the impairment of spatial memory in the eight-arm radial maze in rats Nobuaki Egashira, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara Brain Research, 952: 239-245、2002
  6. Dexamethasone prevents lomg-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats Tomoaki Ikeda, Kenichi Mishima, Tetsuya Yoshikawa, Katsunori Iwasaki, Michihiro Fujiwara, Yi X. Xia, Tsuyomu Ikenoue Behavioral Brain Research, 136: 161-170、2002
  7. Involvement of reduced acetylcholine release in △9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze Kenichi Mishima, Nobuaki Egashira, Yoshiaki Matsumoto, Katsunori Iwasaki, Michihiro Fujiwara Life Sciences, 72: 397-407、2002
  8. Repeated cerebral ischemia induecd hippocampal cell death and inpairments of spatial cognition in the rat Eun-hee Chung, Katsunori Iwasaki, Kenichi Mishima, Nobuaki Egashira, Michihiro Fujiwara Life Sciences, 72: 609-619、2002
  9. Involevement of bcl-family expression in the spatial memory impairment induced by repeated ischemia Keiichi Irie, Kenichi Mishima, Daisuke Ishibashi, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwara Life Sciences, 72: 621-629、2002
  10. Behavioral and histochemical studies in repeated cerebral ischemia in rats Katsunori Iwasaki, Kenichimishima, Michihiro Fujiwara Advances in Behavioral Biology、53: 265-268,2002
  11. The pharmacological characterization of attentional processes using a two-lever choice reaction time task in rats Kenichi Mishima, Megumi Fujii, Naoya Aoo, Tetsuya Yoshikawa, Yoshihiko Fukue, Yoko Honda, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwara Biol. Pharm. Bull., 25(12): 1570-1576, 2002
  12. Impairment of spatial memory in kaolin-induced hydrocephalic rats is associated with changes in the hippocampal cholinergic and noradrenergic contents. Egawa T, Mishima K, Egashira N, Fukuzawa M, Abe K,Yae T, Iwasaki K, Fujiwara M Behav Brain Res 129, 31-39 (2002)
  13. カンナビノイドの治療薬への応用 藤原道弘,三島健一,江頭伸昭 鎮痛・オピオイド研究最前線 pp89-101、2002
  14. 大麻による薬物依存と異常行動 藤原道弘 日本薬理学雑誌, 117: 35-41, 2002
  15. 繰り返し脳虚血による空間認知障害の発症機序:脳血管性痴呆症の動物モデルとしての応用 岩崎克典、三島健一、江頭伸昭、藤原道弘 脳機能の解明-生命科学の主潮流-, pp 239-246, 2002
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2001年

  1. Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine. Hatip-Al-Khatib I, Mishima K, Iwasaki K, Fujiwara M Brain Res 902, 108-118 (2001)
  2. Cholinergic involvement in the improving effects of Yoku-kan-san-ka-chimpi-hange on the disruption of spatial cognition and the electroconvulsive shock-induced immobilization. Egashira N, Mishima K, Kurauchi K, Matsumoto Y, Iwasaki K, Fujiwara M J Trad Med 18, 71-80 (2001)
  3. Selective and long-term learning impairment following neonatal hypoxic-ischemic brain insult in rats. Ikeda T, Mishima K, Yoshikawa T, Iwasaki K, Fujiwara M, Xia YX, Ikenoue T Behav Brain Res 118, 17-25 (2001)
  4. Ameliorative effect of vasopressin-(4-9) through vasopressin V1A receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze. Mishima K, Tsukikawa H, Inada K, Fujii M,Iwasaki K, Matsumoto Y, Abe K, Egawa T, Fujiwara M Eur J Pharmacol 427, 43-52 (2001)
  5. Characteristics of learning and memory impairment induced by △9-tetrahydrocannabinol in rats. Mishima K, Egashira N, Hirosawa N, Fujii M, Matsumoto Y, Iwasaki K, Fujiwara M. Jpn J Pharmacol 87, 297-308 (2001)
  6. Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study. Hatip-Al-Khatib I, Bolukbasi F, Mishima K, Egashira N, Iwasaki K, Fujiwara M Jpn J Pharmacol 87, 277-287 (2001)
  7. Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion. Palacino JJ, Murphy MP, Murayama O, Iwasaki K, Fujiwara M, Takashima A, Golde TE, Wolozin B. J Biol Chem 276, 38563-38569 (2001)
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2000年

  1. Nimodipine improves thedisruption of spatial cognition induced by cerebral ischemia. Taya K, Watanabe Y, Kobayashi H, Fujiwara M Physiol Behav 70, 19-25 (2000)
  2. The scopolamine-induced impairment of spatial cognition parallels the acetylcholine release in the ventral hippocampus in rats. Mishima K, Iwasaki K, Tsukikawa H, MatsumotoY, Egashira N, Abe K, Egawa T, Fujiwara M European J Pharmacol 84, 163-173 (2000)
  3. 大麻による空間認知記憶障害 藤原道弘,三島健一 精神医学レビュー34, 28-35 (2000)
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1999年

  1. Cerebral acetylcholine levels and long-term spatial cognitive impairment following middle cerebral artery occlusion in rats. Urae A, Okada M, TamuraA, Nakagomi T, Kanemitsu H, Mine K, Fujiwara M, Tomonaga M JapanJ Psychopharmacol 19, 267-272 (1999)
  2. 老齢ラット海馬における不飽和脂肪酸とLTP形成の関連?ドコサヘキサエン酸慢性投与の影響? 天本敏昭,岡田三津子,河内明夫,中西 博,矢澤一良,藤原道弘,朝長正道 日本神経精神薬理学雑誌19, 273-278 (1999)
  3. Inhibition of GABA System Involved in Cyclosporine-Induced Convulsions. Shuto H, Kataoka Y, Fujisaki K, Nakao T, Sueyasu M, Miura I, Watanabe Y, Fujiwara M, Oishi R Life Sci, 65, 879-887 (1999)
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1998年

  1. Brain-derived neurotrophic factor stimulates neurite outgrowth in a calretinin-enriched neuronal culture system. Katsunori Iwasaki, Krystyna Isaacs, David Jacobowitz. Intnl.J.Developemental Neuroscience,16: 135-145 (1998)
  2. A synthetic ceramide analog (L-PDMP) up-regulates neuronal function, Annals of the New York Academy of Sciences. Inoguchi J, Mizutani A, Jimbo M, Usuki S, Yamagishi K, Mochizuki H, Muramoto K, Kobayashi K, Kuroda Y, Iwasaki K, Ohgami Y, Fujiwara M Biochem Biophysic Research Commun, 845, 219-224 (1998)
  3. Role of nerve terminal L-type Ca2+ channel in the brain. Watanabe Y, Lawlor GF, Fujiwara M Life Sci 62, 1671-1675 (1998)
  4. L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol stimulates ganglioside biosynthesis, neurite outgrowth and synapse formation in cultured cortical neurons, and ameliorates memory deficit in ischemic rats. Inokuchi J, Kuroda Y, Kosaka S, Fujiwara M. Acta Biochimica Polonica, 45 479-492 (1998)
  5. Extracellular presence of IL-8 in the astrocyte-rich cultured cerebellar granule cells under acidosis. Watanabe Y, Miura I, Ohgami Y, Fujiwara M. Life Sci.,vol.63: 1037-1046,(1998)
  6. A New Muscarinic Partial Agonist, SB202026A, Improved the Deficit of Spatial Cognition Induced by Scopolamine, Pirenzepine and Repeated Ischemia in Rats. Iwasaki K, Mishima K, Chung EH, Ohgami Y, Ishibasi M, Fujiwara M. Naunyn Schniedeberg's Archives of Pharmacology, 358, 35-36 (1998)
  7. Repeated ischemia induced impairment of spatial cognition and cellular apoptosis in the hippocampus CA1 area in the rat. Iwasaki,K.,Chung E-H, Fujiwara,M. J.Neurochem.70:20-23(1998)
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1997年

  1. Physiological levels of β-amyloid peptide stimulate protein kinase C in PC12 cells. Yanquan Luo, Katsunori Iwasaki, D.B.Hawver, Trey Sunderland, Geoge Roth, Benjamin Wolozin. Brain Res.769: 287-295 (1997)
  2. Up-Regulation of Ganglioside Biosynthesis, Functional Synapse Formation, and Memory Retention by a Synthetic Ceramide Analog (L-PDMP). Inoguchi J, Mizutani A, Jimbo M, Usuki S, Yamagishi K, Mochizuki H, Muramoto K, Kobayashi K, Kuroda Y, Iwasaki K, Ohgami Y, Fujiwara M. Biochem Biophysic Research Commun, 237, 595-600 (1997)
  3. Effect of active fragments of arginine-vasopressin on the disturbance of spatial cognition in rats, Behav Brain Res. Fujiwara M, Ohgami Y, Inada K, Iwasaki K. Behav. Brain Res. 83, 91-96 (1997)
  4. Effects of the isocarbacyclin methyl ester clinprost incorporated into lipid microspheres, in focal ischemia of stroke-prone spontaneously hypertensive rats. Tetsuji Yae, Hiroaki Araki, Yusuke Ohgami, Katsunori Iwasaki, Michihiro Fujiwara. Arzneimittelforschung,47: 1200-1203 (1997)
  5. Rolipram and Its Optical Isomers, Phosphodiesterse 4 Inhibitors, Attenuated the Scopolamine-Induced Impairments of Learning and Memory in Rats. Takashi Egawa, Kenichi Mishima, Yoshiaki Matsumoto, Kiyo Iwasaki, Katsunori Iwasaki and Michihiro Fujiwara. Japan.J.Pharmacol.,75: 275-281 (1997)
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1996年

  1. The disruption of spatial cognition and changes in brain amino acid,monoamine and acetylcholine in rats with transient cerebral ischemia. Katsunori Iwasaki, Yoshihisa Kitamura, Yusuke Ohgami, Kenichi Mishima, Michihiro Fujiwara. Brain Res.709: 163-172(1996)
  2. Changes in gene transcription during A_-mediated cell death. Katsunori Iwasaki, Trey Sunderland, John Kusiak and Benjamine Wolozin. Molecular Psychiatry 1: 65-71 (1996)
  3. Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation. Benjamin Wolozin, Katsunori Iwasaki, Pasquale Vito, J. Kelly Ganjei, Emanuela Lacan, Trey Sunderland, Boyu Zhao, John W. Kusiak, Wilma Wasco, Luciano D'Adamio. Science 274(5293): 1710-1713 (1996)
  4. Requirement of the Familial Alzheimer's Disease Gene PS2 for Apoptosis. Opposing Effect of ALG-3. Pasquale Vito, Benjamin Wolozin, Katsunori Iwasaki, J. Kelly Ganjei, Emanuela Lacan and Luciano D'Adamio. J.Biol.Chem. 271 (49): 31025-31028 (1996)
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1995年

  1. Differential role of nucleus accumbens and caudate-putamen in mediating the effect of nomifensine and methamphetamine on ambulation and rearing of rats in the open-field test.Al-Khatib IM, Dokmeci I, Fujiwara M. Jpn J Pharmacol. 67, 69-77 (1995)
  2. Long-term spatial cognitive impairment after middle cerebral artery occlusion in rats: no involvement of the hippocampus. Okada M, Nakanishi H, Tamura A, Urae A, Mine K, Yamamoto K, Fujiwara M. J Cereb Blood Flow Metab. 15, 1012-1021 (1995)
  3. Long-term spatial cognitive impairment following middle cerebral artery occlusion in rats -A behavioral study-Okada M,Tamura A, Urae A, Nakagomi T, Kirino T, Mine K, Fujiwara M.  J Cereb Blood Flow Metab. 15, 505-512 (1995)
  4. 情動と記憶, 藤原道弘、三島健一. Clinical Neuroscience 13, 1044-1047 (1995)
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1994年

  1. 抗うつ薬, 藤原道弘、片岡泰文, 薬局 45, 97-101 (1994)
  2. ステップスルー型受動的回避実験, 岩崎克典, 生体の科学 45, 動物の行動機能テスト-個体レベルと分子レベルを結ぶ- 496-497 (1994)
  3. ステップダウン型受動的回避実験, 岩崎克典, 生体の科学 45, 動物の行動機能テスト-個体レベルと分子レベルを結ぶ- 498-499 (1994)
  4. Morris水迷路実験, 藤原道弘、三島健一, 生体の科学 45, 動物の行動機能テスト-個体レベルと分子レベルを結ぶ- 500-501 (1994)
  5. Biel型水迷路実験, 藤原道弘、三島健一, 生体の科学 45, 動物の行動機能テスト-個体レベルと分子レベルを結ぶ- 508-509 (1994)
  6. 8方向放射状迷路実験, 藤原道弘、三島健一, 生体の科学 45, 動物の行動機能テスト-個体レベルと分子レベルを結ぶ- 510-511 (1994)
  7. 老齢ラットの空間認知獲得に及ぼす当帰芍薬散および当帰の影響, 岩崎貴代、岩崎克典、藏内浩二、藤原道弘, 和漢医薬学雑誌 11, 366-367 (1994)
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1993年

  1. Toki-Syakuyaku-San and Oren-Gedoku-To improve the disruption of spatial cognition induced by cerebral ischaemia and dcentral cholinergic dysfunction in rats. Iwasaki K, Fujiwara M. Phytother Res. 7, 60-62 (1993)
  2. Plasma-free and sulfoconjugated MHPG in major depressive disorders: differences between responders to treatment and nonresponders. Mine K, Okada M, Mishima N, Fujiwara M, Nakagawa T. Biol Psychiatry. 34, 654-660 (1993)
  3. 釣藤散ならびに抑肝散加陳皮半夏の空間認知障害改善作用, 江頭伸昭、岩崎克典、植木昭和、藏内浩二、藤原道弘, 和漢医薬学会誌 10, 190−194 (1993)
  4. 大麻依存, 植木昭和、藤原道弘、岩崎克典, 精神医学シリーズ 5, 薬物依存 209-218 (1993)
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1992年

  1. Effect of nebracetam on the disruption of spatial cognition in rats. Iwasaki K, Matsumoto Y, Fujiwara M. Jpn J Pharmacol. 58, 117-126 (1992)
  2. The facilitating and suppressing effects of Δ9-tetrahydrocannabinol on the rise in intrasynaptosomal Ca2+ concentration in rats. Okada M, Urae A, Mine K, Shoyama Y, Iwasaki K, Fujiwara M. Neurosci Lett. 140, 55-58 (1992)
  3. Effects of the N-methyl-D-aspartate antagonists on the rise in [Ca2+]i following depolarization in aged rat brain synaptosomes. Okada M, Urae A, Iwasaki K, Mine K, Fujiwara M. Brain Res. 583, 227-236 (1992)
  4. 実験的空間認知障害に対する黄連解毒湯ならびに釣藤散の作用, 岩崎克典、大神祐輔、植木昭和、藤原道弘和漢医薬学会誌 8, 476-478 (1992)
  5. 痴呆症, 藤原道弘, 代謝 臨時増刊号 漢方薬 29, 130-143 (1992)
  6. 第4章 脳・脊髄, 藤原道弘, 機能形態学(藤原道弘他編)廣川書店 61-112 (1992)
  7. 第9章 心血管系, 藤原道弘, 機能形態学(藤原道弘他編)廣川書店 235-260 (1992)
  8. 漢方薬 その医学的研究の最先端「痴呆症」, 藤原道弘, 代謝-臨時増刊号- 29, 130-143 (1992)
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1991年

  1. Effect of Toki-syakuyaku-san on scopolamine-induced deficit of learning and memory in rats. Fujiwra M, Iwasaki K, Ogata T. Basic, Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Disease. 2, 379-382 (1991)
  2. 学習障害モデルとしての実験的正常圧水頭症 −抗痴呆薬候補としての漢方方剤−藤原道弘, 脳と神経 43, 63-66(1991)
  3. 電撃ショックならびにscopolamineによるラットの学習記憶障害に及ぼすminaprineの作用, 川島数明、荒木博陽、奥山茂、小友 進、相原弘和、山本経之、植木昭和、藤原道弘, 基礎と臨床 24, 383-388 (1991)
  4. 動物からみた大麻の危険性, 藤原道弘, こころの臨床 10, 9-12(1991)
  5. 老人性痴呆 シリーズ/高齢者の疾患の治療ー医療用漢方製剤を用いてー藤原道弘, 漢方医学 15, 1-5 (1991)
  6. カオリン水頭症ラットの免疫応答について, 上野光一、武田裕夫、佐藤哲男、藤原道弘, Neuroimmunological Res. 4, 35-40 (1991)
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1990年

  1. The Na+-dependent release of endogenous dopamine and noradrenaline from rat brain synaptosomes. Okada M, Mine K, Fujiwara M. J Pharmacol Exp Ther. 252, 1283-1288 (1990)
  2. Differential calcium dependent between the release of endogenous dopamine and noradrenaline from rat brain synaptosomes. Okada M, Mine K, Fujiwara M., J Neurochem. 54, 1947-1952 (1990)
  3. Effect of TJ-23 on the learning and memory disturbance following cerebral ischemia in rats. Fujiwara M, Iwasaki K., Patient Benefit and Japanese Kampo Product 1, 15-20 (1990)
  4. 実験的記憶障害と和漢薬, 藤原道弘, 和漢医薬学会誌 6, 234-237 (1990)
  5. 実験的記憶障害に対する当帰芍薬散の改善作用, 藤原道弘, 神経精神薬理 12, 217-226 (1990)
  6. 高次処理, 藤原道弘, 脳卒中実験ハンドブック 756-782 (1990)
  7. ラット の空間認知獲得に関する基礎的検討, 岩崎克典、松本禎明、藤原道弘動物の学習・記憶試験 -その実際と問題点- 19-34 (1990)
  8. 中枢神経作用の探索 抗躁うつ病薬, 藤原道弘、岩崎克典, 医薬品の開発 9, 医薬品の探索 I, 177-200 (1990)
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1989年

  1. In vivo changes in brain catecholamine release from rat hypothalamus following olfactory bulbectomy, Iwasaki K, Fujiwara M, Ueki S. Pharmacol Biochem Behav. 34, 879-885 (1989)
  2. Δ9-tetrahydrocannabinol facilitates striatal dopaminergic transmission. Sakurai-Yamashita Y, Kataoka Y, Fujiwara M, Mine K, Ueki S. Pharmacol Biochem Behav. 33, 397-400 (1989)
  3. Relative importance of the dopaminergic system in haloperidol-catalepsy and the anticataleptic effect of antidepressants and methamphetamine in rats. Al-Khatib IMH, Fujiwara M, Ueki S. Pharmacol Biochem Behav. 33, 93-97 (1989)
  4. Is the augmentation of K+-evoked intrasynaptosomal Ca2+ concentration due to the influx of Ca2+ in rat brain synaptosomes? Okada M, Mine K, Iwasaki K, Fujiwara M. J Neurochem. 52, 1837-1842 (1989)
  5. Relationship of calcium and adenylate cyclase messenger systems in rat brain synaptosomes. Okada M, Mine K, Fujiwara M. Brain Res. 501, 23-31 (1989)
  6. Ascorbic acid suppresses the deconjugation of noradrenaline but not dopamine in plasma. Okada M, Mine K, Fujiwara M. Analytical Biochem. 182, 262-265 (1989)
  7. アセチルコリン仮設と抗痴呆薬候補, 藤原道弘、岩崎克典, 神経精神薬理 11, 793-805 (1989)
  8. 大黄の行動薬理作用, 藤原道弘、西岡五夫、野中源一郎、植木昭和, 医薬品の開発 2, 薬理活性物質 5, 543-551 (1989)
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1988年

  1. Changes in [3H]-imipramine binding sites in relation to muricide following olfactory bulbectomy and the effect of nomifensine in brain of rats. Al-Khatib IMH, Kataoka Y, Fujiwara M, Ueki S. Archieves Internationals de Pharmacodynamie Therapie. 296, 282-292 (1988)
  2. Effect of microinjection of nomifensine into brain on muricide of olfactory bulbectomized rats. Al-khatib IMH, Fujiwara M, Ueki S. Asia Pacific J Pharmacol. 3, 125-129 (1988)
  3. 実験水頭症における空間記憶障害 −放射状迷路を用いた研究− 岩崎康夫、信楽信行、斎藤勇、高倉公明、八重徹司、岩崎克典、藤原道弘, 小児の脳神経 13, 367-372 (1988)
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1987年

  1. The role of brain catecholamines in the exhibition of muricide induced by nucleus accumbens lesions and the effect of antidepressants in rats. Al-Khatib IMH, Fujiwara M, Iwasaki K, Kataoka Y, Ueki S. Pharmacol Biochem Behav. 26, 351-355 (1987)
  2. Spatial memory disturbance in hydocephalus and the effect of drugs modifying neurotransmitters. Takakura K, Iwasaki Y, Shitara N, Iwasaki K, Fujiwara M. Neurotransmitters and Neuroreceptors. 6, 56-65 (1987)
  3. Noradrenergic involvement in catalepsy induced by △9-tetrahydrocannabinol. Kataoka Y, Ohata H, Fujiwara M, Oishi R, Ueki S. Neuropharmacology. 26, 55-60 (1987)
  4. The involvement of neuropeptide Y in the antimuricide action of noradrenaline injected into the medial amygdala of olfactory bulbectomized rats. Kataoka Y, Sakurai Y, Mine K, Yamashita K, Fujiwara M, Ueki S. Pharmacol Biochem Behav. 28, 101-103 (1987)
  5. 中枢神経作用薬, 藤原道弘, 臨床薬物治療学大系 93-128 (1987)
  6. うつ病と脳内アミンーラットのmuricideについての研究, 植木昭和、藤原道弘、山本経之、柴田重信、岩崎克典, 続「脳の生体警告系」 115-128 (1987)
  7. 大麻の薬理作用, 藤原道弘, 依存性薬物情報シリーズNo. 1 大麻 43-59 (1987)
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1986年

  1. Changes in brain catecholamine levels following olfactory bulbectomy and the effect of acute and chronic administration of desipramine in rats. Iwasaki K, Fujiwara M, Shibata S, Ueki S. Pharmacol Biochem Behav. 24, 1715-1719 (1986)
  2. Activity of some atypical antidepressants on five models of muricide in rat. Al-Khatib IMH, Fujiwara M, Shibata S, Ueki S. Asia Pacific J Pharmacol. 1, 79-85 (1986)
  3. The effect of neurotransmitters on cataleptic behavior induced by PG D2 in rats. Saito R, Fujiwara M, Kamiya H, Ono N. Pharmacol Biochem Behav. 26, 543-546 (1986)
  4. 大黄の向精神作用, 植木昭和、西岡五夫、藤原道弘、野中源一郎現代東洋医学 3, 98-103 (1986)
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1985年

  1. Amantadineの行動薬理学的研究, 藤原道弘、桜井康子、清田義弘、島添隆雄、太田尚、柴田重信、植木昭和、日本薬理学雑誌 85, 259-274 (1985)
  2. Δ9-Tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion. Sakurai Y, Ohta H, Shimazoe T, Kataoka Y, Fujiwara M, Ueki S. Life Sci. 37, 2181-2185 (1985)
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